From SuspireWiki
When one hears a vampire refer to the existing Kindred order as the "despised aristocracy of the undead," the speaker is probably one of these free-thinking spirits - those whom the vampire world has dubbed somewhat misleadingly as one of the "unaligned" or "unbound." They are the rebels, outlaws and iconoclasts of vampire society, those who freely (and often intentionally) flout the so-called rule of the elders among their kind. Independent Kindred can also simply be apolitical vampires, those who acknowledge only their own authority but who don't necessarily make a grand show of defiance against Princes and Regents. There are as many reasons to renounce the entire notion of covenants as there are Kindred among the unbound, everything from paper-tiger rebellion to acknowledging no greater authority than the self to free will to downright bizarre mystic philosophies and even heresies.
The unaligned are fiercely independent, and many would sooner face the rising sun with a smile than spend eternity in submission before another creature of the night. While they do not truly compose a covenant, the unbound are often overlooked individualy and considered in a collective rabble with others of their mindset, despite the fact that they have no shared organization. Still, enough commonalities occur that they can be discussed as a phenomenon, even if their status as a formal covenant is nonexistent. If a vampire disdains the prevailing governmental structure but doesn't belong to any structured covenant of her own, the rest of Kindred society almost always considers her one of the unaligned.
taken from Vampire: the Requiem
How does one survive as an Unaligned in the Kingdom of the Americas?
The answer is very simple: very carefully. While the majority of the Kindred in the Kingdom and their particular Hold have a fall-back on their covenant if things in their night-to-night dealings go sideways, an Unaligned doesn't. This has led to many Unaligned adopting a very careful demeanor, while others have adopted a sinister, intimidating manner in order to try and scare off any potential before it brews.
How then, do Unaligned exist? Many (some would say most) of them have taken up residence in Tijuana, and offer themselves out as mercenaries for hire, either as bodyguards or ruffians. Others have tried to play fence-sitter between covenants, dealing in black market goods, secrets or other less-than-offensive trades. In the end though, an Unaligned has no one to look to but themselves. Unaligned who believe they'll be safe and "desired" (for recruitment) soon find that the negatives far outweigh the benefits of being a carefree soul.